Tutkimuksia haittavaikutuksista

Suomalaisten lääkäreiden julkaisemia tapausselostuksia

• Duodecim Nro 8/2004, Tapausselostus ”Molempien akillesjänteiden repeämä fluorokinolonin komplikaationa”
• Duodecim Nro 19/1996, Tapausselostus ”Molemminpuolinen akillesjänteen tulehdus fluorokinolonihoidon komplikaationa”
• Duodecim Nro 1/2005, Tapausselostus ”Akuutisti kehittynyt lattajalka fluorokinolonin käytön yhteydessä”

 

Fluorokinolonien haittavaikutuksiin liittyviä tutkimuksia ja artikkeleita

Kalifornian yliopistossa on alkamassa tutkimus fluorokinoloniantibioottien haittavaikutuksista. Tutkimukseen etsitään parhaillaan 10,000 vapaaehtoista ja sitä johtaa Tohtori Beatrice A. Golomb.

• University of California, San Diego – Fluoroquinolone Effects Study

• Neurology Today, “New Support for Association Between Fluoroquinolones and Peripheral Neuropathy“
• Peripheral neuropathy associated with fluoroquinolones
• Mechanisms in Medicine, video, “Fluoroquinolones: Mechanisms of Action and Resistance” 
  The Annals of Pharmacotherapy, “Peripheral Neuropathy Associated with Fluoroquinolones“
• New Warnings for Cipro, Levaquin, and other Quinolone Antibiotics

• Reactions to Cipro, Levaquin, and Other Fluoroquinolone Antibiotics
• Fluoroquinolone Toxicity Syndrome: A Letter to the Senate Committee on Health, Education & Labor
• New Warnings for Cipro, Levaquin, and other Quinolone Antibiotics
• Severe Reactions to Levaquin, Cipro and Other Fluoroquinolone Antibiotics: Are Doctors in Denial?

• Emergency Medicine News, “Adverse Reactions to Fluoroquinolones”
• Chang Gung Medical Journal, “Fluoroquinolone-associated Tendinopathy“
• Journal of Antimicrobial Chemotherapy, “Peripheral Sensory Disturbances Related to Treatment with Fluoroquinolones”
• The Journal of Biological Chemistry, “The Mechanism of Inhibition of Topoisomerase IV by Quinolone Antibacterials.”
• Clinical Chemistry, “Interference of Ofloxacin with Determination of Urinary Porphyrins“
• Antimicrobial Agents and Chemotherapy, “Inhibitory effects of quinolone antibacterial agents on eucaryotic topoisomerases and related test systems.“
• Proceedings of the National Academy of Sciences of the United States, Biochemistry, “Quinolone Binding to DNA Mediated by Magnesium Ions” 
• Austin Journal of Computational Biology and Bioinformatics, “Combination of Molecular Modeling and Quantum Mechanical Studies to Understand Quinolone Resistance Mechanism of Mycobacterium Tuberculosis“
• Antimicrobial Agents and Chemotherapy, “Effect of magnesium complexation by fluoroquinolones on their antibacterial properties.“
• Mutation Research, “Ciprofloxacin:  Mammalian DNA Topoisomerase Type II Poison In Vivo“
• International Journal of Developmental Neuroscience, “Analysis of age dependent changes of Topoisomerase II alpha and beta in rat brain.“
• Journal of Neurosurgery, “Abnormal coagulation studies associated with levofloxacin. Report of three cases.“
• PNAS, “Target genes of Topoisomerase IIβ regulate neuronal survival and are defined by their chromatin state“
• Annals of Epidemiology, “Peripheral Neuropathy and Guillain-Barre Syndrome Risks Associated with Exposure to Systemic Fluoroquinolones:  A Pharmacovigilance Analysis“
• Clinical Infectious Diseases, “Temafloxacin Syndrome:  Review of 95 Cases“
• Drug Safety, “The withdrawal of temafloxacin. Are there implications for other quinolones?“
• BMJ, “Ciprofloxacin interacts with thyroid replacement therapy“
• The British Journal of General Practice, “Benzodiazepine tolerance, dependency, and withdrawal syndromes and interactions with fluoroquinolone antimicrobials“
• Antimicrobial Agents and Chemotherapy, “Quinolones, theophylline, and diclofenac interactions with the gamma-aminobutyric acid receptor.”
• Pharmacology Weekly, “What is the mechanism by which the fluoroquinolone antibiotics (e.g., ciprofloxacin, gemifloxacin, levofloxacin, moxifloxacin) can increase a patient’s risk for developing a seizure or worsen epilepsy?“’
• Antimicrobial Agents and Chemotherapy, “The Fluoroquinolone Levofloxacin Triggers the Transcriptional Activation of Iron Transport Genes That Contribute to Cell Death in Streptococcus pneumoniae“
• Antimicrobial Agents and Chemotherapy, “Levofloxacin and Moxifloxacin Increase Human Gut Colonization by Candida Species.“
• BMC Microbiology, “Comparative Transcription Analysis and Toxin Production of Two Fluoroquinolone-Resistant Mutants of Clostridium Perfringens”  FDA write-up
• Current Medicinal Chemistry, “Recent Advances in the Discovery and Development of Quinolones and Analogs as Antitumor Agents”
• Urology, “Quinolone antibiotics: a potential adjunct to intravesical chemotherapy for bladder cancer“
• Journal of Photochemistry and Photobiology, “Structure–activity relationship and role of oxygen in the potential antitumour activity of fluoroquinolones in human epithelial cancer cells“
• Archive of Pharmacology, “From chloroquine to antineoplastic drugs? The story of antibacterial quinolones“
• Asian Pacific Journal of Cancer Prevention, “Comparative Evaluation of Antiproliferative Activity and
  Induction of Apoptosis by some Fluoroquinolones with a Human Non-small Cell Lung Cancer Cell Line in Culture“
• Biochemical Pharmacology, “Quinolone analogue inhibits tubulin polymerization and induces apoptosis via Cdk1-involved signaling pathways“
• Cell Science at a Glance, “Lysosomal cell death at a glance“
• Toxicological Sciences, “Inhibition of Human Topoisomerase IIa by Fluoroquinolones and Ultraviolet A Irradiation“
• Experimental Gerontology, “DNA topoisomerases in mtDNA maintenance and ageing”
• Antimicrobial Agents and Chemotherapy, “Modulation of Gyrase-Mediated DNA Cleavage and Cell Killing by ATP“
• Cancer Biol. Ther., “Ciprofloxacin-induced G2 arrest and apoptosis in TK6 lymphoblastoid cells is not dependent on DNA double-strand break formation”
• The Journal of Biological Chemistry, “Cytotoxicity of Quinolones toward Eukaryotic Cells:  Identification of Topoisomerase II as the Primary Cellular Target for the Quinolone CP-115,953 in Yeast“
• Inorganic Chemistry, “New uses for old drugs: attempts to convert quinolone antibacterials into potential anticancer agents containing ruthenium.“
• Journal of Physiology and Pharmacology, “Ciprofloxacin Inhibits Proliferation and Promotes Generation of Aneuploidy in Jurkat Cells“
• Nepal Medical College Journal, “Genotoxic and cytotoxic effects of antibacterial drug, ciprofloxacin, on human lymphocytes in vitro”
• Toxicology and Applied Pharmacology, “The effects of levofloxacin on rabbit fibroblast-like synoviocytes in vitro.“
• Antimicrobial Agents and Chemotherapy, “Ciprofloxacin Induces an Immunomodulatory Stress Response in Human T Lymphocytes“
• Journal of Leukocyte Biology, “Several Gene Programs are Induced in Ciprofloxacin Treated Human Lymphocytes as Revealed by Microarray Analysis“
• Archives of Toxicology, “A Comparative Analysis of Chromosomal Abberations in Cultured Human Lymphcytes Due to Fluoroquinolone Drugs at Different Expression Periods“
• Food Additives and Contaminants, “Antibodies to the quinolones and fluoroquinolones for the development of generic and specific immunoassays for detection of these residues in animal products.“
• Oxford Journals, “Specific Toxicologic Aspects of the Quinolones“
• Science Translational Medicine, “Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells“
• Free Radical Research, “The mitochondria targeted antioxidant MitoQ protects against fluoroquinolone-induced oxidative stress and mitochondrial membrane damage in human Achilles tendon cells“
• African Journal of Pharmacy and Pharmacology, “Effect of ciprofloxacin and levofloxacin
  on some oxidative stress parameters in brain regions of male albino rats“
• Antimicrobial Agents and Chemotherapy, “Adverse Effects of Antimicrobials via Predictable or Idiosyncratic Inhibition of Host Mitochondrial Components“
• Wyss Institute for Biologically Inspired Engineering at Harvard University, “Dodging Antibiotic Side Effects“
• Journal of Advanced Pharmacy Education and Research, “Fluoroquinolone Induced Neurotoxicity:  A Review“
• American Journal of Pharmacology and Toxicology, “CIPROFLOXACIN INDUCED CHONDROTOXICITY AND TENDINOPATHY“
• Antimicrobial Agents & Chemotherapy, “Diminished Ciprofloxacin-Induced Chondrotoxicity by Supplementation with Magnesium and Vitamin E in Immature Rats“
• Current Microbiology, “Ciprofloxacin-Induced Antibacterial Activity is Reversed by Vitamin E and Vitamin C“
• Archives of Toxicology, “Ciprofloxacin Causes Cytoskeletal Changes and Detachment of Human and Rat Chondrocytes in Vitro“
• Journal of Bone and Joint Surgery, “Fluoroquinolone’s effect on growth of human chondrocytes and chondrosarcomas. In vitro and in vivo correlation.”
• Veterinary Pathology, “In Vitro Evidence of Effects of Magnesium Supplementation on Quinolone Treated Horse and Dog Condrocytes“
• Veterinary and Human Toxicology, “Serum sickness secondary to ciprofloxacin use.”
• Antimicrobial Agents and Chemotherapy, “Serum sickness-like illness associated with ciprofloxacin.“
• Therapeutics, “Effects of fluoroquinolones on cultured articular chondrocytes flow cytometric analysis of free radical production“
• Antimicrobial Agents and Chemotherapy, “Magnesium deficiency induces joint cartilage lesions in juvenile rats which are identical to quinolone-induced arthropathy.”
• Nature Reviews:  Microbiology, “How Antibiotics Kill Bacteria: From Targets to Networks“
• Journal of Neurosciences in Rural Practices, “Levofloxacin Induced Acute Anxiety and Insomnia” 
• Antimicrobial Agents and Chemotherapy, “Effects of Novel Fluoroquinolones on the Catalytic Activities of Eukaryotic Topoisomerase II:  Influence of the C-8 Fluorine Group“
• Pharmaceutics, “Pharmacokinetic Drug Interactions of Antimicrobial Drugs: A Systematic Review of Oxazolidanones, Rifamycines, Macrolides, Fluoroquinolones, and Beta Lactams“
• Chemistry and Biology, “Trovofloxacin, a Fluoroquinolone Antibiotic with Hepototoxic Potential, Causes Mitochondrial Peroxinitrate Stress in a Mouse Model of Underlying Mitochondrial Dysfunction“
• Journal of Pharmacology, “Trovafloxacin Enhances Lipopolysaccharide-Stimulated Production of Tumor Necrosis Factor-α by Macrophages: Role of the DNA Damage Response“
• Current Medicinal Chemistry, “The quinolone family: from antibacterial to anticancer agents.“
• Drug Metabolism and Disposition, “Trovafloxacin-Induced Gene Expression Changes in Liver-Derived in Vitro Systems: Comparison of Primary Human Hepatocytes to HepG2 Cells“
• Molecular Pharmacology, “Delayed Cytotocicity and Cleavage of Mitochondrial DNA in Ciprofloxacin Treated Mammalian Cells”
• European Journal of Medicinal Chemistry, “Antibacterial Action of Quinolones: From Target to Network“
• Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, “Damage to Mitochondrial DNA Induced by the Quinolone Bay y 3118 in Embryonic Turkey Liver” 
• CSH Perspectives, “The Maintenance of Mitochondrial DNA Integrity—Critical Analysis and Update“
• Biochim Biophys Acta, “Mitochondrial DNA Damage and its Consequences for Mitochondrial Gene Expression“
• Toxicology and Applied Pharmacology, “Mitochondrial abnormalities–a link to idiosyncratic drug hepatotoxicity?“
• Antimicrobial Agents and Chemotherapy, “Adverse Effects of Antimicrobials via Predictable or Idiosyncratic Inhibition of Host Mitochondrial Components“
• Reproductive Sciences, “Role of Mitochondria in Ciprofloxacin-Induced Apoptosis in Murine Sperm Cells“
• Environmental Toxicology and Chemistry, “Identification of fluoroquinolone antibiotics as the main source of umuC genotoxicity in native hospital wastewater“
• Antimichrobial Agents and Chemotherapy, “Calcium Signals are Affected by Ciprofloxacin as a Consequence of Reduction of Mitochondrial DNA content in Jurkat Cells“
• The Canadian Journal of Infectious Diseases, “Safety of Fluoroquinolones:  An Update“
• Clinical and Experimental Allergy, “T Cell Mediated Hypersensitivity to Quinolones:  Mechanisms and Cross-Reactivity” delayed reactions
• Clinical Infectious Diseases, “Quinolone Arthropy in Animals vs. Children” (When you see the conclusion that these drugs are safe for children, please take into consideration that the study was commissioned by Pfizer.)
• BMJ Case Studies, “Fluoroquinolone Use in a Child Associated with Development of Osteochondritis Dissecans“
• Toxicology and Applied Pharmacology, “TNF/TNFR1 pathway and endoplasmic reticulum stress are involved in ofloxacin-induced apoptosis of juvenile canine chondrocytes“
• The Journal of Immunology, “Mitochondrial Reactive Oxygen Species Control T Cell Activation by Regulating IL-2 and IL-4 Expression:  Mechanism of Ciprofloxacin Mediated Immunosuppression“
• Antimicrobial Agents and Chemotherapy, “Calcium Signals are Affected by Ciprofloxacin as a Consequence of Reduction of Mitochondrial DNA content in Jurkat Cells“
• Molecular Systems Biology, “Gyrase Inhibitors Induce an Oxidative Damage Cellular Death Pathway in Escherichia Coli“
• Clinical Infectious Diseases, “Risk of Severe Dysglycemia Among Diabetic Patients Receiving Levofloxacin, Ciprofloxacin, or Moxifloxacin in Taiwan“
• BMJ, “Diabetes Inspidus Induced by Ofloxacin“
• Medical Hypotheses, “Fluoroquinolone antibiotics and type 2 diabetes mellitus“
• The Annals of Pharmacotherapy, “Safety Concerns with Fluoroquinolones“
• Canadian Medical Association Journal, “Risk of Acute Kidney Injury Associated With the Use of Fluoroquinolones”
• American Journal of Kidney Diseases, “Levofloxacin-induced granulomatous interstitial nephritis.”
• Toxicology Letters, “Disturbance of Cellular Glucose Transport by Two Prevalently Used Fluoroquinolone Antibiotics Ciprofloxacin and Levofloxacin Involves Glucose Transporter Type 1″
  
• Clinical Infectious Diseases, “Association between recent use of fluoroquinolones and rhegmatogenous retinal detachment: a population-based cohort study.“
• Journal of Rheumatology, “Malignant hyperthermia susceptibility revealed by myalgia and rhabdomyolysis during fluoroquinolone treatment.”
• Antimicrobial Agents and Chemotherapy, “Effects of Ciprofloxacin and Ofloxacin on Adult Human Cartilage In Vitro“
• Physical Medicine and Rehabilitation (PM & R) “Musculoskeletal Complications of Fluoroquinolones: Guidelines and Precautions for Usage in the Athletic Population“
• Clinical Update, “Drug induced muscle disorders“
• The American Journal of Sports Medicine, “Fluoroquinolones Impair Tendon Healing in a Rat Rotator Cuff Repair Model – A Preliminary Study“
• Drugs Under Experimental and Clinical Research, “Possible involvement of nitric oxide in the quinolone-induced tendon lesions in rats.“
• Antimicrobial Agents and Chemotherapy, “Pefloxacin-Induced Achilles Tendon Toxicity in Rodents: Biochemical Changes in Proteoglycan Synthesis and Oxidative Damage to Collagen“
• Physical Therapy, “Physical Therapist Management of Fluoroquinolone-Induced Achilles Tendinopathy“
• Antimicrobial Agents and Chemotherapy, “Characterization of fluoroquinolone-induced Achilles tendon toxicity in rats: comparison of toxicities of 10 fluoroquinolones and effects of anti-inflammatory compounds.“
• Sports Medicine, Arthroscopy, Rehabilitation, Therapy & Technology, “Deciphering the pathogenesis of tendinopathy: a three-stages process”
• Journal of Antimicrobial Chemotherapy, “Contribution of Reactive Oxygen Species to Pathways of Quinolone Mediated Bacterial Cell Death“
• The American Journal of Sports Medicine, “The Effect of Ciprofloxacin on Tendon, Paratenon, and Capsular Fibroblast Metabolism“
• Toxicology, “Fluoroquinolones cause changes in extracellular matrix, signalling proteins, metalloproteinases and caspase-3 in cultured human tendon cells“
• Clinical Infectious Diseases, “Fluoroquinolone-Associated Tendinopathy: A Critical Review of the Literature“
• International Journal of Antimicrobial Agents, “Synergystic Effects of Dexamethasone and Quinolones on Human Derived Tendon Cells“
• Antimicrobial Agents and Chemotherapy, “Ultrastructure of Achilles Tendons of Rats Treated with Ofloxacin and Fed a Normal or Magnesium Deficient Diet“
• Laboratorie de Toxicologie, “In Vitro Discrimination of Fluoroquinolones Toxicity on Tendon Cells:  Involvement of Oxidative Stress“
• Arthritis and Rheumatism, “Ciprofloxacin Mediated Cell Proliferation Inhibition and G2 M Cell Cycle Arrest in Rat Tendon Cells”
• Journal of Young Pharmacists, “Oxidative Stress Induced by Fluoroquinolones on Treatment for Complicated Urinary Tract Infections in Indian Patients“
• Journal of Hazardous Materials, “Oxidative stress response of two fluoroquinolones with catalase and erythrocytes: a combined molecular and cellular study.”
• International Science Index, “Effects of Ciprofloxacin and Levofloxacin Administration on Some Oxidative Stress Markers in the Rat“
• Archives of Biochemistry and Biophysics, “Participation of reactive oxygen species in phototoxicity induced by quinolone antibacterial agents“
• Photodermatology, Photoimmunology & Photomedicine, “Photolocalized purpura during ciprofloxacin therapy.“
• Dermatology Online Journal, “Stasis Dermatitis as a Complication of Recurrent Levofloxacin-Associated Bilateral Leg Edema“
• Drug Metabolism and Disposition, “Acyl Glucuronidation of Fluoroquinolone Antibiotics by the UDP-Gulucuronosyltransferase 1A Subfamily in Human Liver Microsomes“
• Molecular Interventions, “Mechanisms of Pathogenesis in Drug Hepatoxicity Putting the Stress on Mitochondria“
• Medical Hypotheses, “Epigenetic side-effects of common pharmaceuticals: A potential new
  field in medicine and pharmacology“
• African Journal of Pharmacy and Pharmacology, “Ultra structural study of gentamicin and ofloxacin effect
  on testis tissue in rats: Light and transmission electron microscopy“
• Chemico-biological Interactions, “Trovafloxacin, a fluoroquinolone antibiotic with hepatotoxic potential, causes mitochondrial peroxynitrite stress in a mouse model of underlying mitochondrial dysfunction.”
• American Journal of Health-System Pharmacy, “Risk of hepatotoxicity associated with fluoroquinolones: A national case-control safety study“
• The Journal of Pharmacology, “In Vetro Discrimination of Fluoroquinolones on Tendon Cells: Involvement of Oxidative Stress”
• Journal of Pharmacy Practice, “What Role do Fluoroquinolone Antimicrobial Agents Play in Cardiac Dysfunction and Altered Glycemic Control?“
• Annals of Family Medicine, “Azithromycin and Levofloxacin Use and Increased Risk of Cardiac Arrhythmia and Death“
• Journal of Antimicrobial Chemotherapy, “Quinolone-induced QT interval prolongation: a not-so-unexpected class effect“
• Journal of Cardiovascular Electrophysiology, “Proarrhythmia as a class effect of quinolones: increased dispersion of repolarization and triangulation of action potential predict torsades de pointes.“
• BMC Infectious Diseases, “Unnecessary Use of Fluoroquinolone Antibiotics in Hospitalized Patients”
• Clinical Infectious Diseases, “Antimicrobial Safety: Focus on Fluoroquinolones“
• Drug Safety (Journal), “Drug Interactions with Quinolone Antibacterials“
• Department of Pharmacology and Therapeutics, University of Florida College of Medicine, “4 Quinolones Cause a Selective Loss of Mitochondrial DNA from Mouse L1210 Leukemia Cells“
• Antimicrobial Agents and Chemotherapy, “Ciprofloxacin, a Quinolone Carboxylic Acid Compound Active Against Aerobic and Anaerobic Bacteria“
• Antimicrobial Agents and Chemotherapy, “Protein Binding: Do We Ever Learn?“
• The Annals of Pharmacotherapy, “Neurologic adverse effects during concomitant treatment with ciprofloxacin, NSAIDS, and chloroquine: possible drug interaction.”
• The Journal of Family Practice, “The Perils of Prescribing Fluoroquinolones“
• The European Respiratory Journal, “Ciprofloxacin-induced Acute Interstitial Pneumonitis“
• African Journal of Pharmacy and Pharmacology, “Effect of ciprofloxacin and levofloxacin on some
  oxidative stress parameters in brain regions of male albino rats“
• Connecticut Medicine, “A Possible Case of Levofloxacin Associated Amnesia, Depression, and Paresthesia“
• Indian Journal of Psychiatry, “Levofloxacin Induced Acute Psychosis“
• Indian Journal of Pharmacology, “Ofloxacin-induced hallucinations“
• Neurological Sciences, “Levofloxacin-induced delirium“
• General Hospital Psychiatry, “Levofloxacin-induced delirium with psychotic features.“
• Journal of Rheumatology, “Achilles Tendinopathy After Treatment With Ophthalmic Moxifloxacin“
• Biophysical Journal, “Characterization of the Interactions between Fluoroquinolone Antibiotics and Lipids: a Multitechnique Approach“
• Brain Research, “Effects of the quinoline derivatives quinine, quinidine, and chloroquine on neuromuscular transmission.”
• Clinics and Practice, “Fluoroquinolone Toxicity Symptoms in a Patient Presenting with Back Pain“
• Biomed Central: Journal of Medical Case Reports, “Death Following Bilateral Complete Achilles Tendon Rupture in a Patient on Fluoroquinolone Therapy:  A Case Report“
• Indo American Journal of Pharmaceutical Research, “CIPROFLOXACIN INDUCED SYSTEMIC LUPUS ERYTHEMATOSUS“
• Journal of the American Dental Association, “Drug interactions in dentistry: the importance of knowing your CYPs.“
• Pediatric Infectious Disease Journal, “CIPROFLOXACIN IN NEONATES AND ITS POSSIBLE ADVERSE EFFECT ON THE TEETH.“
• Journal of Pharmacology and Pharmacotherapeutics, “Ciprofloxacin-induced erythema multiforme“
• JAMA Ophthalmol, “Flashes, Floaters and Oral Fluoroquinolones”
• Pharmacy World and Science, “Fluoroquinolone use and the change in incidence of tendon ruptures in the Netherlands”
• Hong Kong Medical Journal, “Fluoroquinolone-induced Achilles tendinitis”